Scholarship of multi-level governance has developed into one of the most innovative themes of research in political science and public policy. This accessible Handbook presents a thorough review of the wide-ranging literature, encompassing various theoretical and conceptual approaches to multi-level governance and their application to policy-making in domestic, regional and global contexts. The importance of multi-level governance in specific policy areas is highlighted, and the contributors - an international group of highly renowned scholars - report on the ways in which their field of specialization is or may be affected by multi-level governance and how developments could affect its conceptualization. European integration is considered from its unique standpoint as the key catalyst in the development of multi-level approaches, and the use of multi-level governance in other parts of the world, at both domestic and regional levels, is also considered in detail before focus is shifted towards global governance. The Handbook concludes with a presentation of six policy fields and instruments affected by multi-level governance, including: social policy, environmental policy, economic policy, international taxation, standard-setting and policing.